ATX-104 Light Activated Dermal Filler Under Review

42-15650396Today’s most popular dermal fillers include Restylane, Juvederm and Botox, and hyaluronic acid fillers ar frequently used to correct wrinkles and fine lines, reshape and contour the face, and to create a more youthful appearance. Researchers are now reviewing an innovative dermal filler called ATX-104.

Unlike regular injectables that are simply injected into the skin to produce immediate results, the ATX-104 works only after it comes into contact with an external light source. After it is injected, the filler is shaped and polymerized transdermally with the help of external light.

The ATX-104 filler is based on KYTHERA’s proprietary photochemistry platform and has been developed at Johns Hopkins University. Scientists are studying the effects of the light reaction, and working on ways to optimize the filler so that it can create dramatic results and be used to reshape the face.

Different types of injectable fillers can produce different results based on the strength of the filler, and the person’s existing skin conditions. Hyaluronic acid fillers such as Juvederm and Restylane are commonly used to reshape the face, fill out wrinkles and lines around the mouth and nose, and to correct sagging skin. Botox is most commonly used to correct deep wrinkles on the forehead, but also has other uses including treating headaches and migraines, or stopping sweating.

So far, the ATX-104 system has been able to produce better results than many of the fillers that are readily available. It is still undergoing testing, and Kythera Biopharmaceuticals has announced that the first in-human trial of the light-activated filler was successful.

Kythera Biopharmaceuticals is a biotechnology company based out of California, and was started by former employees of Amgen. It has about $40 million in funding, and is working on the ATX-104 system, along with three other products designed specifically for the aesthetic market.

Further Reading

  • Reducing the signs of aging with facial treatments such as microdermabrasion and dermal fillers can provide temporary results, but innovative procedures such as Fraxel C02 Laser Treatment show more promise for those who want to get rid of fine lines and wrinkles for the long-term.

  • Khloe Kardashian made headlines recently after the paparazzi caught her with the infamous “trout pout” – the result of too many injectable fillers in the lips. Kim Kardashian’s younger sister appeared to have some very swollen and lumpy lips after leaving a Beverly Hills salon last week and many are suspecting that that star had cosmetic surgery. Celebrity plastic surgery doctor Dr. Anthony Youn did not treat Khloe Kardashian but believes that the star did have some type of injectable filler. He tells, “Khloe has a trout pout! The excessively plump appearance of her lips could be due to injections of a filler like Juvederm. Her upper lip is larger than her lower lip, causing her mouth to resemble a trout’s. Most injectable fillers last about 6 months in the lips, so given enough time we may see her lips shrink to a smaller and more typical size.” Another plastic surgery doctor, Dr. Michael Fiorellio who is based in New York City, made a similar conclusion. He suspects that Khloe had some type of filler treatment because, “Her lips look swollen and bruised. The product looks lumpy as well”. Dr. Fiorellio is suggesting that this Kardashian sister had either Juvederm or Restylane injections to make her lips appear larger and fuller. Injectable fillers are among the most popular types of non-invasive cosmetic enhancements around the country, and are an attractive option for women who want to add volume to their lips, fill out hollows in their cheeks, and diminish the appearance of wrinkles and lines. They’re also more affordable than having surgery and can be a convenient option for those who don’t want to deal with the long downtime and recovery process associate with a surgical procedure like lip implants or a facelift.

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