Azfibrocel-T Reviewed by FDA for Wrinkle Reduction

Today’s innovative treatments for wrinkle reduction include laser skin resurfacing treatments, facelift surgery and dermal fillers such as Restylane and Botox. However, cell therapy may be another option for men and women in the United States in the near future.

Fibrocell Sicence, Incorporated, a biotechnology company focused on developing regenerative fibroblast cells for aesthetic, medical and scientific application has announced that the U.S. Food and Drug Administration’s Cellular, Tissue and Gene Therapies Advisory Committee is reviewing azfibrocel-T, an autulogous cell therapy for the treatment of nasolabial fold wrinkles in adults.

The FDA is currently evaluating the treatment under the brand name, Laviv ™. The treatment works by using the patient’s own natural fibroblasts. The fibroblasts are extracted, multiplied and then re-injected into the skin as a personalized treatment, allowing for the formation of new cells and stronger connective tissue fibers. Over time, this results in a significant reduction of wrinkles and fine lines, and creates a healthier, more rejuvenated appearance. Fibrocell Science, Incorporated is planning to continue studes for additional aesthetic and therapeutic sues.

Fibrocell Sicence, Incorporated is the result of the reorganization of Isalogen, Incorporated, a company emerging from bankruptcy. Azfibrocel-T was the sole topic of discussion at the Cellular, Tissue and Gene Therapies Advisory Committee Meeting on October 9, 2009 in Maryland. In may 2009, the FDA accepted azfibrocel-T for the treatment of moderate to severe nasolabial fold wrinkles for full review. The target date for an FDA response under the Prescription Drug User Fee Act is January 4, 2010.

If Laviv ™ becomes available in 2010, the treatment will be joining the ranks of fat transfer procedures, laser skin resurfacing and other skin rejuvenation treatments. Laviv ™ would be made available at many plastic surgery centers and aesthetic centers around the United States.

Further Reading

  • Reducing the signs of aging with facial treatments such as microdermabrasion and dermal fillers can provide temporary results, but innovative procedures such as Fraxel C02 Laser Treatment show more promise for those who want to get rid of fine lines and wrinkles for the long-term.

  • One of the secrets to Jennifer Lopez’s youthful looks is her heart-shaped face. Jennifer’s plump, lifted cheeks help her retain a very youthful appearance and this feature has been deemed the cornerstone of a younger-looking face. As we get older, the fat in our cheeks tends to disappear and this area can even appear hollowed out. Plastic surgeons recommend facial fillers to restore the lost volume in the cheeks or even fat grafting if you want a more permanent solution.

  • While Kim Kardashian has been very public about staying away from plastic surgery procedures, her mother Kris Jenner has become a well-known celebrity plastic surgery addict. Kim K.’s boyfriend Kanye West has been pleading wit Jenner to stop having plastic surgery because he fears that she will end up dead like his own mother Donda West. Donda died tragically at the age of 58 after undergoing a tummy tuck, breast reduction, and liposuction procedure. A close source reveals that, “That loss crushed Kanye”. Since Kanye’s become very close to Kris, he may be feeling that he doesn’t want to lose a second mom to a plastic surgery death.